īasu AP (2017) Mapping corticospinal tract projection patterns in unilateral cerebral palsy. Rex Bookstore Inc, ManilaĪrnould C, Penta M, Renders A, Thonnard J-L (2004) A measure of manual ability in children with cerebral palsy. These results contribute to a better understanding of the underlying neuropathology of upper limb function in children with unilateral CP and point towards a clinical potential of tractography.Īriola MM (2006) Principles and methods of research. Adding lesion timing and CST wiring pattern did not further improve the model of bimanual performance, while for unimanual capacity lesion timing was additionally retained (58%, p = 0.0002). Asymmetry indices of the CST and sensory tracts could best explain bimanual performance (74%, p < 0.0001) and unimanual capacity (50%, p = 0.004). Moderate to high correlations were found between diffusion metrics of the targeted tracts and upper limb function ( r = 0.45–0.72 p < 0.01). Results showed a more damaged CST in children with cortical and deep grey matter lesions ( N = 10) and ipsilateral CST projections ( N = 11) compared to children with periventricular white matter lesions ( N = 24 p < 0.02) and contralateral CST projections ( N = 9 p < 0.025), respectively. Transcranial magnetic stimulation was applied to assess the CST wiring pattern. Streamline count, fractional anisotropy and mean diffusivity were extracted from the targeted tracts and asymmetry indices were additionally calculated.

Thirty-four children (mean age 10 years 7 months ± 2 years 3 months) with unilateral CP underwent a comprehensive upper limb evaluation and diffusion weighted imaging (75 directions, b value 2800). This study explored the role of lesion timing (periventricular white matter versus cortical and deep grey matter lesions) and type of corticospinal tract (CST) wiring pattern (contralateral, bilateral, ipsilateral) on white matter characteristics of the CST, medial lemniscus, superior thalamic radiations and sensorimotor transcallosal fibers in children with unilateral cerebral palsy (CP), and examined the association with upper limb function.

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